(Trimethylsilyl)alanine: a Metabolically Stable 'Bio-Isostere' for Phenylalanine

Abstract

The preparation of protected derivatives of enantiomerically pure β-(trimethylsilyl)alanine (1) and their chemical properties are decribed. Examples of renin inhibitory peptides, containing 1 are given, which demonstrates its use as a 'bio-isosteric' replacement for phenylalanine (2).