(Trimethylsilyl)alanine: a Metabolically Stable 'Bio-Isostere' for Phenylalanine

Authors

  • Beat Weidmann

DOI:

https://doi.org/10.2533/chimia.1992.312

Abstract

The preparation of protected derivatives of enantiomerically pure β-(trimethylsilyl)alanine (1) and their chemical properties are decribed. Examples of renin inhibitory peptides, containing 1 are given, which demonstrates its use as a 'bio-isosteric' replacement for phenylalanine (2).

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Published

1992-08-19