Liquid Chromatographic Resolution and Bioassay of Napropamide Herbicide Enantiomers

Abstract

The enantiomers of the herbicide napropamide (1) were separated on a ?g-scale using chiral liquid chromatography and submitted to a bioassay for herbicidal activity using a wheat germ test. Under these conditions, only one enantiomer showed herbicidal activity. The potential for reducing the application rate of pesticides by omitting isomeric ballast is discussed.