Studien zur Synthese von Vernolepin

Authors

  • R. Scheffold Institut für Organische Chemie der Universität Bern
  • L. Révész Institut für Organische Chemie der Universität Bern
  • J. Aebersold Institut für Organische Chemie der Universität Bern
  • A. Schaltegger Institut für Organische Chemie der Universität Bern

DOI:

https://doi.org/10.2533/chimia.1976.57

Abstract

1-Hydroxymethyl-1-vinyl-3,5-dioxo-cyclohexane 3 is considered as the key intermediate in a synthesis of vernolepin 1. Starting from 3,5-dimethoxybenzoic acid, this ring B precursor 3 was synthesized in a sequence of seven steps with an over-all yield of 35 %. Annellation of the α-methylen-γ-lacton ring C is easily achieved by condensation of 3 with pyruvic acid, followed by dehydration.

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Published

1976-02-29

Issue

Vol. 30 No. 2 (1976): Forschung/Research

Section

Articles

License

Copyright (c) 1976 R. Scheffold

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
R. Scheffold, L. Révész, J. Aebersold, A. Schaltegger, Chimia 1976, 30, 57, DOI: 10.2533/chimia.1976.57.