A New Class of Nucleosides. Synthesis, Reactivity and Biological Activity of Keto-Hexose Nucleosides

Abstract

Direct oxydation of sterically hindered hexosyl purines led to keto-hexosylpurines, important synthetic intermediates. The first unsaturated keto-nucleosides have also been obtained by acetylation of the corresponding keto-hexosyl purines. Most of the keto-hexosyl purines especially those deriving from 6-deoxyhexoses exhibit cell growth inhibitory activity whereas the parent nucleosides, before oxidation, are inactive.