Resolution of (±)-α-(3-benzoylphenyl-)-propionic acid (Ketoprofen) and diastereomeric interaction of its enantiomers with some biological sys

Authors

  • S. Rendić CRC, Compagnia di Ricerca Chimica, 6830 Chiasso, Switzerland; Institute of Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Yugoslavia
  • V. Šunjić CRC, Compagnia di Ricerca Chimica, 6830 Chiasso, Switzerland; Institute of Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Yugoslavia
  • F. Kajfež CRC, Compagnia di Ricerca Chimica, 6830 Chiasso, Switzerland; Institute of Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Yugoslavia
  • N. Blažević CRC, Compagnia di Ricerca Chimica, 6830 Chiasso, Switzerland; Institute of Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Yugoslavia
  • T. Alebić-Kolbah CRC, Compagnia di Ricerca Chimica, 6830 Chiasso, Switzerland; Institute of Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Yugoslavia

DOI:

https://doi.org/10.2533/chimia.1975.170

Abstract

The (+)-enantiomer of α-(3-benzoylphenyl)-propionic acid obtained from the racemate via diastereomeric amide formation with R-(+)-α-phenylethylamine, showed a positive Cotton-effect (CD) at 223nm (which indicated S-absolute configuration), and it interacted more strongly with human serum albumin as well as with biotransformation enzymes than (−)-enantiomer.

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Published

1975-04-30

Issue

Vol. 29 No. 4 (1975): Forschung/Research

Section

Kurze Mitteilungen

License

Copyright (c) 1975 S. Rendic

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
S. Rendić, V. Šunjić, F. Kajfež, N. Blažević, T. Alebić-Kolbah, Chimia 1975, 29, 170, DOI: 10.2533/chimia.1975.170.