Stereoselectivity in Enzymic Biotransformation of Chiral and Achiral 1,3-Dihydro-2H-1,4-Benzodiazepin-2-ones

Authors

  • S. Rendić CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)
  • V. Šunjić CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)
  • F. Kajfež CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)
  • L. Klasinc CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)
  • P. Mildner CRC (Compagnia di Ricerca Chimica), CH-6830 Chiasso (Switzerland); Institute of Organic Chemistry and Biochemistry, Zagreb (Yugoslavia)

DOI:

https://doi.org/10.2533/chimia.1974.232

Abstract

Enzymic biotransformation of chiral 1,4-benzodiazepin-2-ones (S and R forms) is found to be configuration dependent for hydroxylation in aromatic rings, but hydroxylation in position 3, as well as N1-demethylation prooved to be nonstereospecific.

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Published

1974-05-31

Issue

Vol. 28 No. 5 (1974): Forschung/Research

Section

Kurze Mitteilungen

License

Copyright (c) 1974 S. Rendic

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
S. Rendić, V. Šunjić, F. Kajfež, L. Klasinc, P. Mildner, Chimia 1974, 28, 232, DOI: 10.2533/chimia.1974.232.