The mutagenicity of benzimidazole and benzimidazole derivatives III . The influence of the 2-substituent in benzimidazole on the mutagenic activity

Authors

  • J.P. Seiler Swiss Federal Research Station for Arboriculture, Viticulture and Horticulture, CH-8820 Wädenswil (Switzerland)
  • H. Limacher Swiss Federal Research Station for Arboriculture, Viticulture and Horticulture, CH-8820 Wädenswil (Switzerland)

DOI:

https://doi.org/10.2533/chimia.1973.68

Abstract

A number of 2-substituted benzimidazoles has been prepared and the compounds were characterized by their physico-chemical and spectral properties. - Mutagenicity tests with two strains of Salmonella typhimurium revealed that on one hand the mutagenic activity of these compounds tends to parallel their respective pKa's, but that on the other hand the benzimidazoles with larger sized 2-substituents are comparatively less active mutagenic compounds.

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Published

1973-02-28

Issue

Vol. 27 No. 2 (1973): Forschung/Research

Section

Articles

License

Copyright (c) 1973 J.P. Seiler

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
J. Seiler, H. Limacher, Chimia 1973, 27, 68, DOI: 10.2533/chimia.1973.68.