Synthese eines Dekapeptids mit der biologischen Aktivität des Schweine-LH-Releasing-Faktors

Authors

  • Wolfgang Voelter Chemisches Institut der Universität, 74 Tübingen, Wilhelmstraße 33.
  • Karl Zech Chemisches Institut der Universität, 74 Tübingen, Wilhelmstraße 33.

DOI:

https://doi.org/10.2533/chimia.1972.313

Abstract

A synthesis of a decapeptide with the biological activity of the LH releasing factor is described. By coupling N- and side chain protected amino acids to the glycine resin the peptide resin with the desired amino acid sequence is built up. By cleavage with DMF/NH3 the following protected peptide is obtained: Boc-Pyroglu-His (DNP)-Trp-Ser(Bzl)-Tyr(Bzl)-Gly-Leu-Arg-(NO2)-Pro-Gly-NH2 

After treatment with CH2Cl2/TFA, 2-mercaptoaethanol and hydrogenation the product is purified on a Sephadex G 25 column. The LH releasing activity is compared with an extract of the eminentia mediana.

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Published

1972-06-30

Issue

Vol. 26 No. 6 (1972): Forschung/Research

Section

Kurze Mitteilungen

License

Copyright (c) 1972 Wolfgang Voelter

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
W. Voelter, K. Zech, Chimia 1972, 26, 313, DOI: 10.2533/chimia.1972.313.