Informationstheoretisches Modell der Carcinogenese

Abstract

The effects of chemical and physical agents on genetic material have been explained by the interaction of the cell with its immediate environment. Another possibility of cancerogenesis stems from the thermodynamic- and information theory-based premise that cancerogens must all act on the genom of a cell with the same code.

In animal organisms the 10¹⁰ internal and external receptors and the nerve cells of the central, peripheral and intramural systems are the only means available for the transformation of external stimuli into the organism’s own code (RNA, DNA and proteins). By way of the interaction of the epithelial cells (high rate of cell division) and the nerve cells in the adult organism unable to reproduce) which both originate from the same germ layer, arises after many thousands of cell generations through the “reversible production of code molecules” an “exo-DNA” (phase 1). The combination of these “quasi-virus-DNA” with the DNA of the mother cell (i. e. epithelial cell) would produce a tumor cell which over many generations whould develop into an autonomous, host-specific parastited organism (phase 2).