Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer

Authors

  • Sarah Saint-Auret Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France
  • Anne-Caroline Chany Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France
  • Virginie Casarotto Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France
  • Cédric Tresse Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France
  • Lise Parmentier Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France
  • Hajer Abdelkafi Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France
  • Nicolas Blanchard Université de Strasbourg CNRS, Laboratoire de Chimie Moléculaire UMR 7509 67000 Strasbourg, France. n.blanchard@unistra.fr

DOI:

https://doi.org/10.2533/chimia.2017.836

Keywords:

Buruli ulcer, Diverted total synthesis, Mycolactone, Total synthesis

Abstract

Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.
CHIMIA Vol. 71 No. 12 (2017): Natural Products: Source of Innovation

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Published

2017-12-01

Issue

Vol. 71 No. 12 (2017): Natural Products: Source of Innovation

Section

Scientific Articles

License

Copyright (c) 2017 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
S. Saint-Auret, A.-C. Chany, V. Casarotto, C. Tresse, L. Parmentier, H. Abdelkafi, N. Blanchard, Chimia 2017, 71, 836, DOI: 10.2533/chimia.2017.836.