Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research
DOI:
https://doi.org/10.2533/chimia.2018.758PMID:
30514417Keywords:
Genetic encoding, Photo-affinity probe, Photo-cross-linker, Protein–protein interaction, Target identificationAbstract
Photo-cross-linkers are invaluable tools for identifying drug targets and off-targets as well as probing the binding sites in medicinal chemistry and chemical biology. In this review, we summarize recent development of the ligand-based and genetically encoded photo-cross-linkers and their use in biological system. In particular, we highlight our discovery of 2-aryl-5-carboxytetrazole (ACT) as a novel class of photo-cross-linkers and their successful applications in drug target identification as well as identifying transient protein–protein interaction complexes in mammalian cells.Downloads
Published
2018-11-30
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Section
Scientific Articles
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Copyright (c) 2018 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
[1]
Chimia 2018, 72, 758, DOI: 10.2533/chimia.2018.758.