Discovery of Eco-compatible Synthetic Paths by a Multi-catalysis Approach

Authors

  • Jean Rodriguez Aix-Marseille Univ., CNRS Centrale Marseille, iSm2 Marseille, France
  • Adrien Quintard Aix-Marseille Univ., CNRS Centrale Marseille, iSm2 Marseille, France;, Email: adrien.quintard@univ-amu.fr

DOI:

https://doi.org/10.2533/chimia.2018.580

Keywords:

Copper, Enantioselective synthesis, Eco-compatibility, Iron, Multi-catalysis, Organocatalysis

Abstract

This article summarizes our recent developments in the discovery of multi-catalytic reactions. By efficiently taking the best from different worlds, the combination of several catalytic principles allows the invention of eco-compatible transformations rapidly assembling simple building blocks into elaborated enantioenriched molecules. This type of approach was successfully illustrated in the synthesis of cyclohexenones, keto-diols or in the direct functionalization of allylic alcohols by an enantioselective borrowing hydrogen. In addition, mechanistic understanding of the role of the different constituents enabled the fine-tuning of the catalytic systems considerably improving the efficiency notably in terms of enantiocontrol.

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Published

2018-09-01